Please use this identifier to cite or link to this item: http://tcc.fps.edu.br:80/jspui/handle/fpsrepo/695
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dc.contributor.authorCORREIA, Marcela da S. Lira-
dc.contributor.authorSANTOS, Bruno Aires dos-
dc.contributor.authorSANTANA, Aila Karla M.-
dc.date.accessioned2020-04-14T11:51:29Z-
dc.date.available2020-04-14T11:51:29Z-
dc.date.issued2011-
dc.identifier.urihttp://tcc.fps.edu.br:80/handle/fpsrepo/695-
dc.descriptionOrientação: Aila Karla M. Santanapt_BR
dc.description.sponsorshipThiazide diuretic is a first-line class of antihypertensive drug that has been used in treatments of arterial hypertension for 40 years. In this work, a study of imposed degradation of hydrochlorothiazide was performed in order to evaluate the specificity of the analytical method applied for its identification and quantification. Hydrochlorothiazide active pharmaceutical ingredient and the hydrochlorothiazide tablet LAFEPE (25 mg) were undergo the following degrading stress conditions: thermolysis, hydrolysis (acidic, neutral and alkaline), oxidation, photolysis and exposure to metal ions. The protocol applied to quantify the hydrochlorothiazide content in pills and raw material is described in the 5th edition of Brazilian Pharmacopoeia by using high performance liquid chromatography (HPLC). It was observed seven degradation products eluted in different retention times in the chromatogram and none of them overlapped the peak of the active product. The drug and IFA were stable during thermolysis and also photolysis. The degrading agents: oxidation and alkaline hydrolysis, were the ones which generated higher number of products, on the other hand the neutral hydrolysis produced higher percentage of degradation. Indeed, this analytical methodology presented specificity towards hydrochlorothiazide analysis. In addition, the method can indicate product stability and is able to be validated.pt_BR
dc.language.isootherpt_BR
dc.subjectHydrochlorothiazidept_BR
dc.subjectStress testpt_BR
dc.subjectStabilitypt_BR
dc.subjectHigh performance liquid chromatographypt_BR
dc.titleEstudos de degradação forçada no insumo farmacêutico ativo hidroclorotiazida e na forma farmacêutica comprimido, para desenvolvimento e validação de método indicativo de estabilidade por cromatografia líquida de alta eficiência (CLAE)pt_BR
dc.typeOtherpt_BR
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